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african trypanosomiasis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) DNA/RNA Synthesis (2) GSK-3 (1) Parasite (21) Phosphodiesterase (PDE) (1) Proteasome (1)
By Research Areas:	Cancer (3) Infection (21)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153021

NMT-IN-1	Parasite	Infection
NMT-IN-1 (compound 9) is a potent N-Myristoyltransferase (NMT) Inhibitor with IC₅₀ values of 31 and 66 μM for TbNMT and hNMT, respectively. NMT-IN-1 can be used in research of african trypanosomiasis .

HY-155655

JC-229

Parasite Infection

JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

JC-229	Parasite	Infection
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

HY-120060

GNF6702	Parasite	Infection
GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis .

HY-103056

DDD85646 IMP-366	DNA/RNA Synthesis Parasite	Infection
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .

HY-N12636

Kagimminol A	Parasite	Infection
Kagimminols A is a cembrene-type diterpenoids and can be isolated from an Okeania sp. marine cyanobacterium. Kagimminols A shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .

HY-119594

Melarsoprol	Parasite	Infection
Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important drug for African *trypanosomiasis*. Melarsoprol is also active against leukemia cell lines and plasma cells from myeloma patients. Melarsoprol increases the biliary output of GSH in rats .

HY-145287

S-MGB-234	DNA/RNA Synthesis Parasite	Infection
S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines .

HY-151195

20S Proteasome-IN-4	Proteasome Parasite	Infection
20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC₅₀ of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) .

HY-Q40175

Antitrypanosomal agent 9	Parasite	Infection
Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC₅₀ of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research .

HY-122382

Levofuraltadone NF-602	Parasite Bacterial	Infection
Levofuraltadone (NF-602) is an antibacterial and antiparasitic agent. Levofuraltadone has anti-trypanosomiasis activity and can be used in the study of human african trypanosomiasis as well as bacterial infections .

HY-B0744

Eflornithine Maximum Cited Publications 10 Publications Verification DFMO; MDL71782; RMI71782; α-difluoromethylornithine	Parasite	Infection Cancer
Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

HY-B0744A

Eflornithine hydrochloride DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride	Parasite	Infection Cancer
Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

HY-B0744B

Eflornithine hydrochloride hydrate Maximum Cited Publications 10 Publications Verification DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate	Parasite	Cancer
Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women .

HY-155024

HAT-IN-8

Parasite Infection

HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .

HAT-IN-8	Parasite	Infection
HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .

HY-N12637

Kagimminol B	Parasite	Infection
Kagimminol B, a cembrene-type diterpenoid, can be isolated from an Okeania sp. marine cyanobacterium. Kagimminol B shows selective growth-inhibitory activity against the causative agent of human **African trypanosomiasis** .

HY-19910

Acoziborole 1 Publications Verification SCYX-7158; AN5568	Parasite	Infection
Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the *T. b. brucei* S427 strain, the MIC value for SCYX-7158 is 0.6 µg/mL .

HY-155025

Antitrypanosomal agent 14	Parasite GSK-3	Infection
Antitrypanosomal agent 14 (Compound 1) is a T. brucei inhibitor (EC₅₀: 0.47 μM). Antitrypanosomal agent 14 inhibits TbGSK3 with an IC₅₀ of 12 μM. Antitrypanosomal agent 14 can be used for the research of Human African trypanosomiasis .

HY-N3418

Kolavenol	Parasite	Infection
Kolavenol is a diterpene, which can be isolated from Entada abyssinica. Kolavenol's diastereoisomer exhibits trypanocidal activity with an IC₅₀ value of 2.5 μg/mL (8.6 μM) against Trypanosoma brucei rhodesiense. While Trypanosoma brucei rhodesiense is the causing factor of the acute form of human African trypanosomiasis .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC₅₀ of 80 nM .

HY-155732

NPD-2975	Parasite	Infection
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC₅₀0 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC₅₀ values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .

HY-150506

SPR7	Parasite	Infection
SPR7 (compound 7) is a potent and selective rhodesain inhibitor, with a K_i of 0.51 nM. SPR7 shows antiparasitic activity against T. b. brucei, with an EC₅₀ of 1.65 μM .

HY-119480

Megazol	Bacterial	Infection
Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC₅₀ of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .

Melarsoprol	Parasite	Infection
Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important drug for African *trypanosomiasis*. Melarsoprol is also active against leukemia cell lines and plasma cells from myeloma patients. Melarsoprol increases the biliary output of GSH in rats .

Kagimminol A	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Parasite
Kagimminols A is a cembrene-type diterpenoids and can be isolated from an Okeania sp. marine cyanobacterium. Kagimminols A shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .

Kagimminol B	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Parasite
Kagimminol B, a cembrene-type diterpenoid, can be isolated from an Okeania sp. marine cyanobacterium. Kagimminol B shows selective growth-inhibitory activity against the causative agent of human **African trypanosomiasis** .

Kolavenol	Structural Classification Terpenoids Source classification Diterpenoids Solidago altissima Linnaeus Plants Compositae	Parasite
Kolavenol is a diterpene, which can be isolated from Entada abyssinica. Kolavenol's diastereoisomer exhibits trypanocidal activity with an IC₅₀ value of 2.5 μg/mL (8.6 μM) against Trypanosoma brucei rhodesiense. While Trypanosoma brucei rhodesiense is the causing factor of the acute form of human African trypanosomiasis .

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african trypanosomiasis

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Natural
Products